Shin Megami Tensei: After testing the waters by releasing Revelations: Persona and Persona 2: Eternal Punishment on the PSone, the Shin Megami Tensei series has become Atlus's flagship RPG series. Developed by the renowned R&D1 studio, the series is known for challenging gameplay and mature themes in each of its many and varied installments. Shin Megami Tensei: Nocturne, Digital Devil Saga 1 & 2, and Devil Summoner 1 & 2, and Strange Journey have showcased artist Kazuma Kaneko's designs with stunningly detailed graphics perfectly evoking the series' stylish modern aesthetic.

Trauma Center: An unexpected hit early in the lifecycle of the popular Nintendo DS handheld system, Trauma Center: Under the Knife was another creation of Atlus's internal studios that was met with great success upon its American release. The saga of a fledgling doctor working to eradicate the mysterious disease known as GUILT proved popular enough to gain a sequel, which exceeded its predecessor's success as it launched alongside Nintendo's revolutionary new Wii console. The series has continued its prosperity, delivering three additional entries including the recent critically acclaimed Trauma Team for Wii in 2010.

Demon's Souls: One of the biggest sleeper hits of all time, Demon's Souls single-handedly redefined the boundaries between single- and multiplayer roleplaying experiences. The game's revolutionary online functionality boasted passive and active interactivity between players, both cooperative and competitive in nature, throughout a substantial adventure set in a desolate world. Uniquely haunting visuals and sounds treated daring adventurers to entirely original gaming wonders and helped establish Demon's Souls as one of the most relevant, impactful video games ever made.